MANTIS® Liquid Dispenser

Small, Versatile, Precise

Volume Range

Min: 0.1 µL

Max: ∞

Technology

Micro-Diaphragm Pumps

+ Continuous Flow

Precision

CV <2%

@ 0.1 µL

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More Than a Reagent Dispenser

While traditional handheld pipettes or larger automated liquid dispensers greatly deteriorate in accuracy and precision below 2 µL volumes, the Mantis automated liquid dispenser excels at low-volume dispensing in a wide variety of scientific workflows.

The system is an easy and affordable solution to quickly increase the reproducibility and quality of your research as well as the throughput and efficiency of your laboratory. The diaphragm-based chip design is liquid class compatible, easily dispensing aqueous and organic solutions. Additionally, the Mantis will dispense in any SBS template from 6 to 1536 well plates and can be easily programmed to dispense to custom designs as needed.

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Reduce Costs

Save on Reagents and Consumables

Miniaturize reactions with tipless dispensing

Reproducible and Accurate

Enhanced Precision & Accuracy

Dispense volumes down to 100 nL at CV < 2%

Versatile and Flexible

Dispense and Normalize with Ease

Reagent dispensing for a broad range of applications

Benefits

High Precision and Reproducibility: Dispense volumes as low as 100 nL with exceptional consistency (CV < 2%), enabled by the new High-Fidelity Chips that ensure even tighter control over dispense accuracy and precision

Efficient: Miniaturize reactions, scale up throughput, save on reagents, and remove pipette tip cost, saving time and resources across the board

Tackle High-Viscosity and Diverse Reagents: The continuous flow chips enable accurate dispensing of thick fluids like 70% glycerol, DMSO, beads, and mastermix—ensuring broad reagent compatibility for various workflows

Reliability and Traceability with Every Dispense: The Mantis ensures reliable dispensing with droplet verification, real-time LED status, automated breach detection, and RFID tracking for accurate, traceable results and enhanced uptime across your workflows

Fast, Error-Free Setup with CSV Templates: Seamlessly import CSV templates for quick and error-free experiment setup, streamlining workflows and reagent normalization

Fast Labware Setup with Intuitive Control: Define labware in seconds with the Interactive Labware Teaching module, and enjoy a streamlined setup process through an intuitive user interface

Compatible with a Broader Range of Plates: The Adaptable Plate Clamp is gentle enough to accommodate even thin-bottomed plates

Biosafety Cabinet Compatible: With its compact dimensions (350 mm x 232 mm x 212 mm), the Mantis can be used in various biosafety cabinets to accommodate workflows that require this level of safety

Automation Friendly: Integrate effortlessly with external systems, fostering connectivity and data synchronization

Seamless Operation in Regulatory Environments: The system features optional 21 CFR Part 11 Capable Software

Small Footprint: All these new features are packed within the same small footprint

Broad Range of Applications

Assay Development and Design of Experiment (DoE)
Next Generation Sequencing (NGS) - Library Preparation
Polymerase Chain-reaction (PCR) Workflows Real-time and Digital
Enzyme-Linked Immunosorbent Assays (ELISA)
Cell Culture and Bead-Based Assays
Scaling Up Organoid Cultures
3D Cell Culture

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"Automated liquid dispensing is normally associated with big expensive equipment. Not so the Mantis. It combines speed and accuracy with an extremely small footprint and a relatively decent price tag. For us it has become an integral part of single cell processing and NGS applications. Handling is straight forward and intuitive and even my automation averse lab colleagues love to use it."

Wolfgang Breitwieser

Head of Molecular Biology

Enjoy Peace of Mind that Your Dispenses were Precise and Accurate

Optimize your workflow and ensure reliable results with the new Quality Control (QC) Droplet Detection Station. The QC station uses LEDs and optical sensors to confirm proper chip function by detecting the presence of dispensed drops. This technology allows the Mantis to automatically verify if drops are dispensed at the beginning and end of each run, providing both further confidence in dispense quality and traceability. This feature also eliminates the need for manual priming, saving you time and minimizing the risk of errors. With the QC station, you can have complete confidence that your Mantis chips are functioning properly throughout the dispensing process, delivering trustworthy results.

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Large Capacity Chip Changer (LC3) Upgrade

The LC3 enhances the Mantis system by allowing storage for up to 24 chips with a single LC3, or up to 48 chips when using a dual LC3 configuration. This upgrade is fully integrated into the Mantis software, enabling seamless operation. It also incorporates RFID technology to automatically identify all chips stored on the LC3. The LC3 is available as an option with new Mantis instruments or can be added as an upgrade to existing units.

Enhance Laboratory Efficiency

Efficient research means that reagent dead volumes, tip consumption, and reaction volumes are minimized.

The Mantis liquid dispenser dispenses volumes from 100 nL to 100s of mL allowing researchers to commonly run 2-5 µL reaction volumes in genomics and screening workflows.

To minimize dead volume, reagents plug directly into the microfluidic chip. Dead volumes are further reduced to just 6 μL by using pipette tips as reagent reservoirs, making the Mantis ideal for dispensing even the most precious reagents.

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2 uL qPCR Reactions

¼ Volume Sequencing Reactions

What is “Reaction Miniturization”?

Normalize Your Assay Plate, Quickly and Easily

Streamline your assay plate preparation with precision and speed. The Mantis liquid dispenser simplifies normalization by combining intelligent software with our high-performance chip technology:

The Mantis software automatically calculates the normalization values for you
The Continuous Flow (CF) chip bulk dispenses at >600 µL/sec, quickly normalizing each sample tube, well, and plate
Dispense high viscous solvents such as 100% glycerol using High Viscosity CF chip

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Quickly normalize your assays with continuous flow dispensing

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Mantis dispensing 100% glycerol

"Using Mantis, I recently performed a high-throughput qPCR-based drug screen in stem cell derived retinal cells and acquired reliable data with homogeneity, precision, and faster dispensing. The instrument is user-friendly and has easily paid for itself in the savings associated with both expensive reagents and tip consumption in our lab. The Mantis is an essential tool for any lab that wishes to perform the most efficient and reproducible genetic analysis.”

A testimonial from John Hopkins University about the MANTIS Microfluidic Liquid Dispenser

Srinivas R. Sripathi

Wilmer Eye Institute at the Johns Hopkins School of Medicine

Dispense Beads and Cells with Ease

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Magnetic beads are an efficient means for extracting and purifying nucleic acids. Conventional pipetting may result in the non-uniform dispensing of mag beads, leading to a lack of reproducibility. The ability of the Mantis to precisely dispense high viscosity liquids allows uniform dosing of beads reducing operating costs and plastic waste.

Cells can be extremely sensitive, requiring additional care during handling, making the scalability of assays very challenging. The dispensing action of the Mantis liquid dispenser is gentle enough to dispense even the most delicate cells, such as primary neurons, while maintaining cell viability.

Tip-Free Magnetic Bead-based DNA Purification

Cell Dispensing in a Primary Neuron Based Screening

Use of Microfluidic Technology in Mantis

At the core of our dispensers is patented microdiaphragm pump that meters and dispenses discrete volumes of liquid. This valve cluster can fill and dispense as fast as 10 times per second (exact speed depends on specific product). This proven technology is both incredibly precise and viscosity independent.

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Assessment of the Precision of the Microfluidic Pumps

Automated Dispensing, Now for Harsh Chemicals

The Mantis XL Chip is our largest-volume diaphragm chip, enabling accurate 50 µL dispensing in a single actuation. Designed with a perfluoroelastomer (PFE) diaphragm and fluorinated ethylene propylene (FEP) body, it delivers exceptional chemical compatibility for aggressive solvents and corrosive reagents. With CV < 2%, dead volume as low as 70 µL, and no calibration required, the XL PFE Chip brings new levels of robustness, scalability, and precision to demanding chemistry workflows.

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Learn More About the XL Chip

"The Mantis microdispenser is a valuable addition to our proteomics laboratory. By enabling rapid dispensing of reagents and standards with high accuracy and low dead volumes, Mantis greatly facilitates and improves the reproducibility of sample preparation. The ease of operation and setting up new workflows facilitates the implementation of new sample preparation protocols."

Johan Gobom

Associate Professor

Institute of Neuroscience and Physiology

Highly Reproducible Data

Since liquid handling imprecision impacts experimental reproducibility, researchers consider CVs to be a vital factor when considering the automation of their research.

At the core of the Mantis' microfluidic dispensing chip is a valve cluster that measures and dispenses discrete volumes of liquid. This valve cluster has two micro-diaphragms (select either 100 nL and 500 nL or 1 μL and 5 μL) that can fill and dispense as rapidly as 10 times per second.

Low Volume Chip	CV*
0.1 μL	1.4%
0.5 μL	0.5%
1 μL	0.4%

High Volume Chip	CV*
1 μL	0.8%
5 μL	1.1%
10 μL	0.5%
25 μL	0.4%

Continuous Flow Chip	CV*
25 μL	0.3%
50 μL	0.4%
100 μL	0.3%
200 μL	0.2%

* = The coefficient of variation (CV) is the average of three independent microfluidic Chip readings.

Volume Verification

How to perform an “In-House Verification”

What is “Positive Displacement Technology”?

"...[The Mantis liquid dispenser] helps us minimizes variation in sample prep. It is the most economical way to for us to reliably dispense sub-microliter volumes to each of our wells and help minimize our volumes..."

A testimonial from the North Eastern University about the MANTIS Microfluidic Liquid Dispenser

Ed Emmott

Research Associate

Versatility for Any and All Labs

The Mantis dispenses any reagent efficiently and reproducibly regardless of volume, viscosity, temperature, concentration, and research experience. It is no wonder that every year, more and more researchers discover and obtain the Mantis for dispensing reagents as a part of their diverse set of scientific workflows.

Sequencing Technologies

Miniaturize your cDNA synthesis and library preparation reactions, even with limited starting material.

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Cell & Bead-Based Assays

Gentle and even distribution of suspension, adherent and 3D cell cultures.

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PCR Technologies

Enhance the cost-effectiveness
of any qPCR plate preparation workflow.

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Assay Development & Screening

Simplify the evolution from assay design to drug discovery.

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Nucleic Acid Workflows

Automate nucleic acid workflows with precise, tipless dispensing.

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"FORMULATRIX is providing products that are state of the art in terms of fluidic and nanofluidic liquid handling. The technological excellence of these liquid handlers allows us to develop tailored scientific solutions that are extremely relevant for our collaborators' applications and workflows."

Marion Helsmoortel

Development Engineer

Mantis ROI Calculator

Determine a Return on Investment for the Mantis system vs pipetting with disposable tips. Every lab is uniquely operated and, therefore, return on investment calculators are only as good as the information entered.

User Account Management System

The Mantis software allows seamless operation in regulatory environments including controlling user access and tracking user history. Our user management system will help you run your Mantis liquid dispenser in GLP, 21 CFR Part 11, or other regulatory environments by controlling user permissions and storing an official audit trail for your records.

Here are some key benefits of the Mantis 21 CFR Part 11 "capable" software:

User Account Management

Restrict user access and instrument control by locally defined permission levels
Lock users after failed login attempts
Set and manage password requirements
Archive old users, keep all user records

Secure Audit Trail Logging

Date and time stamped user-action and instrument action records
Full instrument and user-action electronic records are stored in a secure database
Export log files to password-protected PDFs
Selectively manage log elements included in your audit trails
Audit trails maintained for the lifetime of the instrument

User Account Management feature in the software of the MANTIS Microfluidic Liquid Dispenser

Publications

Citations: 196Product: Mantis®

An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day

Klingeberg et al., 2026 |Molecular & Cellular Proteomics |Link

Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing chromatography and MS acquisition Here we present an advanced cellenONE protocol for loss-reduced tissue processing and compare all Evosep ONE Whisper Zoom gradients and samples per day along with three common DIA acquisition schemes on a ...More |

Shake and bake: a robust and cost- effective sample preparation workflow for plasma and cerebrospinal fluid

Gobom et al., 2025 |Pre Print |Link

Plasma and cerebrospinal fluid are complementary sources of biomarkers for neurodegenerative diseases The wide dynamic range of protein abundances particularly in plasma hampers detection of low-abundance proteins Depletion of high-abundance proteins and efficient enzymatic digestion can improve proteome coverage but must be carefully optimized for reproducibility throughput and cost-efficiency for ...More |

CRISPR-RfxCas13d screening uncovers Bckdk as a post-translational regulator of the maternal-to-zygotic transition in teleosts

Huertas et al., 2025 |The EMBO Journal |Link

The Maternal-to-Zygotic transition MZT is a reprograming process encompassing zygotic genome activation ZGA and the clearance of maternally-provided mRNAs While some factors regulating MZT have been identified there are thousands of maternal RNAs whose function has not been ascribed yet Here we have performed a proof-of-principle CRISPR-RfxCas d maternal screening ...More |

Spatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets

Makhmut et al., 2025 |Molecular Systems Biology |Link

High-grade serous ovarian cancer HGSOC is a devastating disease that is frequently detected at an advanced and incurable stage Advances in ultrasensitive mass spectrometry-based spatial proteomics have provided a unique opportunity to uncover early molecular events in tumorigenesis and common dysregulated pathways with high therapeutic potential Here we present a ...More |

Discovery and Structural Optimization of 2‑Hydrazinopyrimidin-4one Analogs Inhibiting Human ADP-Ribosylhydrolase ARH3

Heiskanen et al., 2025 |ACS Chemical Biology |Link

Poly-ADP-ribosylation at sites of DNA damage catalyzed by PARP enzymes activates the DNA damage response chromatin remodeling and DNA repair The modification is reversed by two enzymes in humans PARG which efficiently hydrolyzes the poly-ADP-ribose chains and ARH which is the key enzyme for removing the last proximal mono-ADP-ribose from ...More |